Volunteers needed for study on probiotics and low mood

We are looking for volunteers aged 18-55 who are experiencing low mood and/or loss of interest/motivation to take part in a study investigating the effects of 4-week ingestion of a probiotic or placebo on the processing of emotions.

First of all, we ask potential participants to fill in an online questionnaire. Those who score within particular ranges will receive a brief phone call and will be invited to a screening session. If you are deemed eligible to take part, you will then be invited to 2 additional study visits (~3.5h in total) and will be randomly allocated to a 4-week treatment with a probiotic or placebo. In addition to taking the supplement, the study will involve using a device (watch) to measure sleep, providing saliva and blood samples, completing some questionnaires and performing computer based tasks involving the presentation of emotional and non-emotional stimuli.

All sessions will be held at the Warneford Hospital. Time and reasonable travel expenses will be reimbursed on production of receipts.

If you are interested and would like more information, please contact oxpalm@psych.ox.ac.uk.


Reasonable travel expenses will be reimbursed on production of receipts.
Regarding time and effort, if you are not deemed eligible after the first session, you will receive £10. If you complete the study, you will receive £90 + up to £10 based on your performance on a computer task.

Date required

Sessions take place during working hours, scheduled according to participants' availability.


Department of Psychiatry, University of Oxford


If you would like further information on this study, please contact Rita Baiao, either by telephone (01865 613 128) or e-mail (oxpalm@psych.ox.ac.uk).

More information at psych.ox.ac.uk

Clinical Trial Registration Details

OxPALM: Oxford study on Probiotics and Low Mood (Ethics Reference: R58085/RE001)