Seeking volunteers with early Alzheimer’s disease for minocycline trial

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Running across the Thames Valley, this trial aims to determine whether a drug called minocycline is superior to placebo in affecting the disease course over a 2-year period in patients with very early Alzheimer’s disease.

Researchers will measure whether the drug is effective in reducing the rate of decline in cognitive and functional outcomes. The trial will also assess the safety and tolerability of minocycline using standard tests of haematopoetic, renal and hepatic function as well as documentation of skin reactions, gastrointestinal and neurological symptoms.

To be considered you must:

  1. Have a diagnosis or possible / probable Alzheimer’s Disease
  2. Have a Standardised Mini-Mental State Examination (MMSE) score which is greater than 23
  3. If taking Alzheimer’s disease medication (memantine or cholinesterase inhibitor) you must have been on stable dose for at least 8 weeks
  4. Have renal and hepatic function within normal limits
  5. Be able to give informed consent.

Date required

Ongoing

Organisation

Oxford Health NHS Foundation Trust
Berkshire Healthcare Foundation Trust/Research and Development

Contact

Debbie Cooper
Oxford Health NHS Foundation Trust
deborah.cooper@oxfordhealth.nhs.uk
01865902124

Lynn Rigby
Berkshire Healthcare Foundation Trust
lynn.rigby@berkshire.nhs.uk
01183785700