Seeking people with subcortical ischemic vascular dementia for innovative clinical trial

Oxford Health NHS Foundation Trust is looking for volunteers to join this clinical trial.

The aim of this study (the AFFECT Trial) is to test the theory that treatment with amlodipine (a drug used in the treatment of high blood pressure and anginal chest pain) can improve the health of patients affected by subcortical ischemic vascular dementia.

The AFFECT Trial is a 52-week long study looking to find out how effective amlodipine is when compared to a placebo. Volunteers need to be willing to undertake a range of memory tests and undergo two brain scans in a specially designated imaging unit. There will be a total of nine visits.

Patients will be selected using a two stage process:

i) Diagnosis of a relevant dementia syndrome with characteristics of SIVD
ii) A brain scan confirming the presence of a substantial subcortical vascular disease.

Patients will be eligible to participate in the study if they fulfil the inclusion criteria.

Date required



NIHR Clinical Research Network: Thames Valley and South Midlands


Rowena Johns,
01865 902927