Ground breaking trial seeks participants – can we slow down the progression of Alzheimer’s disease?

RADAR is a ground breaking trial that hopes to find out if a drug commonly used to treat high blood pressure (known as hypertension) could slow down the progression of Alzheimer’s disease. We believe the drug called losartan could slow down the rate of brain shrinkage that is known to occur in Alzheimer’s.

RADAR will use brain images (made using Magnetic Resonance Imaging (MRI)) at the beginning and end of the study to measure whether losartan reduces brain shrinkage and memory problems in Alzheimer’s.

The RADAR study is a double-blinded placebo-controlled randomised trial, meaning that participants will be randomly assigned to receive either the study drug or a placebo and nobody will know until the end what they received. This is one of the most powerful study designs available.

The trial will test the benefit of losartan in people with Alzheimer’s while we will also interview someone (whom we call an informant) who spends a lot of time with them. This could be a partner, a carer, a family member or someone else chosen by the volunteer.

This trial will last for approximately 14 months and participants will have a total of nine appointments, several at the beginning and then every 3 months.

During the trial participants will:

  • Attend the local research site at least three times for tests that could take between 1-3 hours
  • Take one study tablet per day
  • Complete further tests and questionnaires as either hospital visits, or the research site or at home, whichever is more convenient for you
  • Be asked to give blood samples at various visits
  • Undergo two Magnetic Resonance Imaging scans (MRI), one at the start and one at the end of the study.

To be eligible, participants need to:

  • Be older than 55
  • Already have a diagnosis of Alzheimer’s
  • Have an informant who will join the trial and attend visits with you
  • Be able to give consent to join the trial yourself.

Date required

Ongoing

Organisation

Oxford Health NHS Foundation Trust

Contact

Chrissie Dransfield
christine.dransfield@oxfordhealth.nhs.uk
07825 377996