Seeking people with Parkinson’s and their family members to help researchers identify genetic traits

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Imperial College London is a clinical site for the Parkinson’s Progression Markers Initiative (PPMI), a large-scale study exclusively focused on identifying and validating Parkinson’s disease biomarkers. Following the successful completion of recruitment for the original study and launch of a pre-motor arm in 2013, PPMI has expanded to study certain Parkinson’s-related genes. This study is funded by Michael J Fox Foundation.

Over the past decade, studies of the genetics of Parkinson’s disease (PD) have revolutionized the pursuit of a “disease-modifying” treatment – a therapy that can slow or stop the progression of PD. Therefore, studying people with Parkinson’s and their families is essential to help researchers identify genetic traits that may contribute to the onset and progression of PD.

Today, PPMI (www.michaeljfox.org/ppmi) is seeking people with Parkinson’s and their family members to help researchers identify genetic traits that may contribute to the onset and progression of PD. Specifically, PPMI is currently studying the connection between PD and having a mutation in the LRRK2 gene – the single most common genetic contributor to PD.

How you can participate:

People with and without PD who meets one of the following criteria may be eligible for genetic counseling and testing at no cost to determine if they may qualify for this study.

  • People with Parkinson’s Disease (PD) who are of Eastern European (Ashkenazi) Jewish descent
  • People with PD North African Berber, or Basque ancestry and a first degree relative with Parkinson’s
  • People with PD and a first degree relative with Parkinson’s
  • Individuals without PD who are related to someone with PD AND who are of Eastern European (Ashkenazi) Jewish, North African Berber, or Basque ancestry.

Fill out a brief online questionnaire at www.michaeljfox.org/ppmi/genetics.

If you have already been genetically tested and know that you have a LRRK2 mutation, then contact the study team on +44 (0) 203 311 1714.

A decision to play a part in PPMI is an opportunity to join forces with thousands of families worldwide committed to speeding scientific progress toward a cure for Parkinson’s disease. PPMI is a $60 million study and is sponsored by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).

Date required

Ongoing study

Organisation

Imperial College NHS trust and Imperial College London

Contact

Bina Shah at
Tel: +44 (0) 203 311 1714
Email: Parkinson.ResearchTeam@imperial.nhs.uk
You can also learn more about genetics and PPMI on http://www.ppmi-info.org/