Do you have memory problems or a diagnosis of Mild Cognitive Impairment? Volunteers needed to test a new medicine

Oxford Health NHS Foundation Trust is looking for participants to take help test a new medication (MK8931) in the treatment of Mild Cognitive Impairment (MCI).

This medication acts to reduce the levels of a brain protein called amyloid, which is known to build up in excessive amounts in those with, or at risk of, Alzheimer’s disease.

The study will also measure how well people are able to tolerate the medication, and monitors for any side effects.

Can I take part?

We are looking for people who meet the following criteria:

  • Aged 50-85
  • Currently experiencing mild memory problems, or have a diagnosis of MCI
  • Be willing and able to have 6 brain scans during the study
  • Have a relative or friend able to come to the visits as a study partner
  • Be otherwise fit and well, with no major health issues
  • Be fluent in English, and to be able to see and hear well enough to complete questionnaires with research team

What will happen if I take part?

In this study people will be randomly allocated to taking the study medication or having a dummy drug (called a placebo). You have a 2 in 3 chance of being given the study medication. The medication is in tablet form and you will be asked to take this once a day.

The study lasts for 80 weeks. During the study we ask you to come to the hospital every three months, with more frequent visits during the visit 4 weeks of the study. The appointments will include similar assessments to the screening visit.

Each visit will last between 1-4 hours, and your study partner should also attend with you.

Date required



Oxford Health NHS Foundation Trust


Ann Murphy
01865 902694